Andrée-Ann Baril, Ph.D.

Assistant Research Professor (2023 - )
Department of Medicine, Université de Montréal
andree-ann.baril@umontreal.ca

Training

Posdoctoral fellowship in Psychiatry (McGill University)
Posdoctoral fellowship in Neurology and Epidemiology (Boston University)
Ph.D. in Biomedical Sciences (Université de Montréal)

Research interests

Investiguate the association between insomnia and sleep disturbances in relation with Alzheimer's disease risk, and underlying mechanisms

Methodological approaches

Polysomnography, actigraphy, 'omics' research (proteomics, genomics), neuroimaging, neuropsychology, cognitive behavioral therapy for insomnia

Fundings

New Investigator Grant, Operating Grant
Alzheimer Society of Canada
Canadian Institutes of Health Research - Aging Institute
Role: Principal investigator
Title: Plasma biomarkers of Alzheimer's disease in insomnia before and after cognitive behavioral therapy for insomnia
Years: 2023-2026

Operating grant
Canadian Institutes of Health Research
Role: Co-investigator
Title: Longitudinal health trajectories related to patterns of cannabis use in veterans with posttraumatic stress disorder
Years: 2022-2026

Digital Research Alliance of Canada
Role: Co-investigator
Title: Thousands of nights to millions of data to build personalized sleep medicine
Years: 2022-2023

Project grant
Canadian Institutes of Health Research
Role: Co-investigator
Title: Brain alterations and cognitive decline in obstructive sleep apnea
Years: 2022-2027

My team

Marie-Josée Quinn

Medical Laboratory Technician

Aurélie Boivin de Billy

Medical Laboratory Technician

Research Associate

Tyna Paquette, M.Sc.

Research Associate

David Lévesque, Ing.

Software Developer

Julien Beaudry, B. Ing, M.Sc.

Software Developer

Selected publications

Baril AA, Pinheiro AA, Himali JJ, Beiser A, Sanchez E, Pase MP, Seshadri S, Demissie S, Romero JR. Lighter sleep is associated with higher enlarged perivascular spaces burden in middle-aged and elderly individuals. Sleep Medicine, In press.

Baril AA, Beiser AS, Decarli C, Himali D, Sanchez E, Cavuoto M, Redline S, Gottlieb D, Seshadri S, Pase MP*, Himali JJ* (*These authors contributed equally). Self-reported sleepiness associates with greater brain and cortical volume and lower prevalence of ischemic covert brain infarcts in a community sample. SLEEP, accepted.

Baril AA, Beiser A, Sanchez E, Mysliwiec V, Redline S, Gottlieb DJ, O’Connor GT, Gonzales MM, Himali D, Seshadri S, Himali J*, Pase M* (*These authors contributed equally). Insomnia symptom severity and cognitive performance: moderating role of APOE genotype. Alzheimer’s & Dementia, 2022, 18(3), 408-21.

Nicolazzo J, Xu K, Lavale A, Buckley R, Yassi N, Hamilton G, Maruff P, Baril AA, Lim YY, Pase M. Sleep symptomatology is associated with greater subjective cognitive concerns: Findings from the community-based Healthy Brain Project. SLEEP, 2021, zsab097.

Baril AA, Beiser AS, Redline S, McGrath ER, Gottlieb DJ, Aparicio JH, Seshadri S, Himali JJ*, Pase MP* (*These authors contributed equally). Interleukin-6 interacts with sleep apnea severity when predicting incident Alzheimer’s disease dementia. Journal of Alzheimer’s Disease, 2021, 79(4), 1451-57.

Baril AA, Beiser AS, Mysliwiec V, Sanchez E, DeCarli CS, Redline S, Gottlieb DJ, Maillard P, Romero JR, Satizabal CL, Zucker JM, Seshadri S, Pase MP*, Himali JJ* (*These authors contributed equally). Slow-wave sleep and MRI markers of aging in a community-based sample. Neurology, 2021, 96(10), e1462-1469.

Baril AA, Beiser AS, Redline S, McGrath ER, Aparicio JH, Gottlieb DJ, Seshadri S, Pase MP*, Himali JJ* (*These authors contributed equally). Systemic inflammation as a moderator between sleep and incident dementia. SLEEP, 2021, 44(2), zsaa164.

Baril AA, Carrier J, Lafrenière A, Warby S, Poirier J, Osorio RS, Ayas N, Dubé MP, Petit D, Gosselin N, on behalf of the Canadian Sleep and Circadian Network. Biomarkers of dementia in obstructive sleep apnea. Sleep Medicine Reviews, 2018, 42, 139-148

Projects

Epidemiological link between sleep disturbances and Alzheimer's disease risk and cognitive, neuroimaging, proteomics, and genomics biomarkers in large cohorts. 

Plasma biomarkers of Alzheimer's disease and inflammation in diagnosed insomnia before and after cognitive behavioral therapy for insomnia.

Optimal sleep characteristic determinants of the regulation of physiological functions with proteomic blood-based signatures.