Simon Warby, Ph.D.

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Assistant Professor
Department of Psychiatry, Université de Montréal
Holder of the Chair Pfizer, Bristol-Myers Squibb, SmithKline Beecham, Eli Lilly in psychopharmacology at the Université de Montréal
514-338-2222
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Education:
Post-doctorate in Psychiatry (Stanford University)
Post-doctorate in Medical Genetics (University of British Columbia)
Ph.D. in Neuroscience (University of British Columbia)

Research Interests:
The genetic basis and modifiers of sleep disorders. The genetic and molecular regulation of normal brain activity during sleep. Pathophysiology and associations between sleep disorders and neurodegenerative/psychiatric diseases. Polysomnography (PSG) and electroencephalography (EEG) - based biomarkers of disease.

Methodologies:
Computational analysis of PSG and EEG signals, genetics and genome-wide association studies, bioinformatics. Molecular biology and molecular genetics including cloning. DNA/RNA/protein assessment & interactions, and in vitro assays.

Now recruiting Graduate Students and Postdoctoral Fellows

Chosen Publications:

Gottlieb DJ, Hek K, Chen T, Watson NF, Eiriksdottir G, Cornelis M, Warby SC, Bandinelli S, Byrne EM, Cherkas L, Evans DE, Grabe HJ, Lahti J, Li M, Lehtimäki T, Lumley T, Marciante KD, Pérusse L, Psaty BM, Robbins J, Tranah GJ, Vink JM, Wilk JB, Andrews JS, Bellis C, Biffar R, Bouchard C, Cade B, Curhan GC, Eriksson JG, Ewert RE, Ferrucci LF, Fülöp TF, Gehrman PR, Goodloe R, Harris TB, Heath AC, Hernandez D, Hofman A, Hottenga JJ, Hunter DJ, Jensen MK, Johnson AD, Kähönen MK, Kao LK, Kraft P, Larkin EK, Lauderdale DS, Luik AI, Medici MM, Montgomery GW, Palotie A, Patel SR, Pistis G, Porcu E, Quaye L, Raitakari O, Redline S, Rimm EB, Rotter JI, Smith AV, Spector T, Teumer A, Uitterlinden AG, Vohl MC,  Widen E, Willemsen G, Young TY, Zhang X, Liu Y, Blangero J, Boomsma DI, Gudnason V, Hu F, Mangino M, Martin NG, O’Connor GT, Stone KL, Tanaka T, Viikari J, Gharib SA, Punjabi NM, Räikkönen K, Völzke H, Mignot E, Tiemeier H. Novel loci associated with usual sleep duration: The CHARGE Consortium genomewide association study. Molecular Psychiatry 2015 Oct; 20(10): 1232-9.

Warby SC, Wendt SL, Welinder P, Munk EGS, Carrillo O, Sorensen HBD, Jennum P, Peppard PE, Perona P, Mignot E.  2014. Sleep spindle detection: crowdsourcing and evaluating performance of experts, non-experts, and automated methods.  Nature Methods.  Apr;11(4):385-92. PMID: 24562424.

Doufas AG, Tian L, Frances Davies M, Warby SC.  2013.  Nocturnal arterial desaturation is associated with pain in subjects suffering from sleep-disordered breathing: a retrospective phenotype-genotype analysis of the Cleveland Family Study.  Anesthesiology Nov;119(5):1149-62.  PMID: 24025612.

Han F, Lin L, Warby SC, Faraco J, Li J, Dong SX, An P, Zhao L, Wang LH, Li QY, Yan H, Gao ZC, Yuan Y, Strohl KP, Mignot E.  2011.  Narcolepsy Onset Is Seasonal and Increased following the 2009 H1N1 Pandemic in China. Annals of Neurology 70:410-7.  PMID:21866560.  [See commentary: PMID 21866561 and PMID 21984118].

Kornum BR, Kawashima M, Faraco J, Lin L, Rico TJ, Hesselson S, Axtell RC, Kuipers H, Weiner K, Hamacher A, Kassack MU, Han F, Knudsen S, Li J, Dong X, Winkelmann J, Plazzi G, Nevsimalova S, Hong SC, Honda Y, Honda M, Hogl B, Ton TG, Montplaisir J, Bourgin P, Kemlink D, Huang YS, Warby S, Einen M, Eshragh JL, Miyagawa T, Desautels A, Ruppert E, Hesla PE, Poli F, Pizza F, Frauscher B, Jeong JH, Lee SP, Strohl KP, Longstreth WT, Jr., Kvale M, Dobrovolna M, Ohayon MM, Nepom GT, Wichmann HE, Rouleau GA, Gieger C, Levinson DF, Gejman PV, Meitinger T, Peppard P, Young T, Jennum P, Steinman L, Tokunaga K, Kwok PY, Risch N, Hallmayer J, Mignot E. 2011.  Common variants in P2RY11 are associated with narcolepsy.  Nature Genetics 43:66-71.  PMID:21170044.

Warby SC, Montpetit A, Hayden AR, Carroll JB, Butland SL, Visscher F, Collins JA, Semaka A, Hudson TJ, Hayden MR.  2009.  CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup.  American Journal of Human Genetics 84:351-66.  PMID:19249009.