Valérie Mongrain, Ph.D.

Associate Professor
Department of Neuroscience, Université de Montréal
Canada Research Chair in Sleep Molecular Physiology
Director of the Molecular Sleep Physiology Lab
514-338-2222 ext. 3323
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Education:
Post-doctorate in Neurosciences (University of Lausanne)
Post-doctorate in Psychiatry (McGill University)
Ph.D. in Neurological Sciences (Université de Montréal)
M.Sc. in Neurological Sciences (Université de Montréal)

Research Interests:
The molecular regulation of sleep and biological rhythms. Links between sleep homeostasis and synaptic plasticity. Involvement of synaptic adhesion proteins in regulating sleep. Pathophysiology of sleep disorders and associations between sleep disorders and psychiatric diseases.

Methodologies:
Electrophysiology (EEG and EMG), EEG spectral analysis, telemetry, molecular biology (e.g., quantification of messenger RNA and protein expression, and of protein-protein and protein-DNA interactions by immunoprecipitation).

Academic Link:
http://neurosciences.umontreal.ca/recherche/les-chercheurs/valerie-mongrain/

Chosen Publications:
Areal CC, Warby SC, Mongrain V. Sleep loss and structural plasticity. Curr Opin Neurobiol 2017, 44, 1-7.

O'Callaghan EK, Ballester Roig MN, Mongrain V. Cell adhesion molecules and sleep. Neurosci Res 2016, in press.

Freyburger M, Pierre A, Paquette G, Bélanger-Nelson E, Bedont J, Gaudreault PO, Drolet G, Laforest S, Blackshaw S, Cermakian N, Doucet G, Mongrain V. EphA4 is involved in sleep regulation but not in the electrophysiological response to sleep deprivation. Sleep 2016, 39(3), 613-624.

Massart R, Freyburger M, Suderman M, Paquet J, El Helou J, Bélanger-Nelson E, Rachalski A, Koumar OC, Carrier J, Szyf M, Mongrain V. The genome-wide landscape of DNA methylation and hydroxymethylation in response to sleep deprivation impacts on synaptic plasticity genes. Transl Psychiatry 2014, 4, e347.

El Helou J, Bélanger-Nelson E, Freyburger M, Dorsaz S, Curie T, La Spada F, Gaudreault PO, Beaumont É, Pouliot P, Lesage F Frank MG, Franken P, Mongrain V. Neuroligin-1 links neuronal activity to sleep-wake regulation. PNAS USA 2013, 110(24), 9974-9979.