Gilles Lavigne, D.M.D., Ph.D.
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Full Professor Faculty of Dentistry, Université de Montréal Dean, Faculty of Dentistry, Université de Montréal Director of the Pain, Sleep and Traumatology Laboratory Holder of the Canada Research Chair on Pain, Sleep and Traumatic injuries 514-343-6005 This email address is being protected from spambots. You need JavaScript enabled to view it.
Education: Ph.D. in Dentistry (University of Toronto) Certificate in Oral Medicine (Georgetown University) M.Sc. in Neurological Sciences (Université de Montréal) D.M.D. (Université de Montréal)
Research Interests: Clinical neurophysiology of sleep and pain, as well as specific disorders including sleep bruxism, sleep apnea, and periodic leg movements during sleep. Psychophysiology of vigilance and pain. Placebo effects of analgesia, and the influence of analgesia (morphine and other opiods on sleep). Orofacial pain and oral medicine.
Methodologies: Polysomnography, spectral analysis of cardiac variability and cerebral activity, morphology of respiratory waves in relation to oromandibular and nasal structure, and psychophysiological pain evaluations using quatitative methods.
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Research
Pain, sleep and traumatology
In the population, between 10 and 30% of people, varying with age, report chronic pain and about 2/3 of these patients complain of non restorative sleep. A bad sleep night (fragmented with frequent awekenings, limbs movement and respiratory abnormalities) exacerbates pain and, inversly, a day with pain altears the ability to fall asleep and maintain sleep. A pattern could be installed: a vicious cycle between pain and sleep could affect life quality, daytime alertness and promotes anxiety and mood swings. In the factors that initiate or maintain pain in relation with sleep, there is the patient history of bad sleep hygiene, anxious and depressifs symptoms, catastrophizing events and sleep disorders (insomnia, periodic limbs movement disorder, obstructive sleep apnea). In addition, some predispositions or vulnerabilities could be in cause for sensory alteration leading to hypervigilance and pain.
The laboratory of Pain, Sleep and Traumatology aim to understand the sleep-pain interaction in population with muscoloskeletal pain, head aches as well as acute or chronic post-traumatic pain. On one hand, we aim to target biological factors (enzymatic, genetic), medical factors (cormorbidities) and psychophysiological factors (cyclic activities of the central nervous system and autonomic nervous system) which could contribute to initiate or maintain the pain-sleep vicious cycle in some individuals and not others. On the other hand, we have multiple projects aiming to understand the effect of sleep on the placebo analgesia (conditionning effect and relief expectations), the relationship between the use of painkillers and sleep loss (opiate analgesics and others) as well as the low efficiency of painkillers when sleep is affected. Finally, the study of bruxism (teeth grinding) during sleep allowed our laboratory to better understand the relationship between excessive muscular activity, pain, respiration and ponctual increases in autonomic nervous system activity. This research projects are financed with a Canada Research Chair in pain, sleep and traumatic injuries, the CIHR, FRQ-S and the Réseau Québécois de recherche sur la douleur.
Team
Lab Members:

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Isabelle Dumais, B.Sc. M.Sc. candidate in Biomedical Sciences, Université de Montréal Role of respiration during sleep in cephalea and bruxism
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Serguei Marshansky, B.Sc. Ph.D. candidate in Biomedical Sciences, Université de Montréal Quantitative analysis of the relation between respiratory events and autonomic micro arousals in a clinic population with sleep apnea |

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Dorrie Rizzo, B.Sc. Ph.D. candidate in Biomedical Sciences, Université de Montréal Should we target all individuals with sleep apnea as high risk drivers: A behavioral and psychological risk profile |
Previous Lab Members:

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Caroline Arbour, Ph.D. Postdoctoral Fellow, Université de Montréal Co-direction with Dre Nadia Gosselin Sleep disorders and neuroanatomical changes in cortical integration of nociceptive signals, and the development of chronic pain after a moderate to severe traumatic brain injury |

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Samar Khoury, Ph.D. Ph.D. in Neurological Sciences, Université de Montréal Genetics of pain and sleep in brain trauma patients
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Maria Clotilde Carra, Ph.D. Ph.D. in Biomedical Sciences, Université de Montréal Role of REM sleep on the genesis of bruxism, and interaction between headaches and sleep bruxism in adolescents
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Geneviève Chaput, M.Sc. M.Sc. in Education Sciences, McGill University Co-direction with Dre Susanne Lajoie Assessing the relationship between pain catastrophizing and early physical, psychological, and cognitive symptoms following mild traumatic brain injury
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Florian Chouchou, Ph.D. Postdoctoral Fellow The role of REM sleep on pain perception following analgesia induced through either morphine or placebo: quantitative evaluations, experimental challenges and relevance to clinical medicine
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Publications
Chouchou F, Chauny JM, Rainville P, Lavigne GJ. Selective REM Sleep Deprivation Improves Expectation-Related Placebo Analgesia. PLoS One 2015, 10(12), e0144992.
Raphael KG, Janal MN, Sirois DA, Dubrovsky B, Wigren PE, Klausner JJ, Krieger AC, Lavigne GJ. Masticatory muscle sleep background electromyographic activity is elevated in myofascial temporomandibular disorder patients. J Oral Rehabil 2013, 40(12), 883-891.
Chouchou F, Khoury S, Chauny JM, Denis R, Lavigne GJ. Postoperative sleep disruptions: a potential catalyst of acute pain? Sleep Med Rev 2014, 18(3), 273-282.
Lavigne GJ, Okura K, Abe S, Huynh N, Montplaisir JY, Marchand S, Lanfranchi P. Gender specificity of the slow wave sleep lost in chronic widespread musculoskeletal pain. Sleep Med 2011, 12(2), 179-185.
Carra MC, Macaluso GM, Rompré PH, Huynh N, Parrino L, Terzano MG, Lavigne GJ. Clonidine has a paradoxical effect on cyclic arousal and sleep bruxism during NREM sleep. Sleep 2010, 33(12), 1711-1716.
Delessert A, Espa F, Rossetti AO, Lavigne GJ, Tafti M, Heinzer R. Pulse wave amplitude drops during sleep are reliable surrogate markers of changes in cortical activity. Sleep 2010, 33(12), 1687-1692.
Laverdure-Dupont D, Rainville P, Montplaisir J, Lavigne G. Relief expectation and sleep. Rev Neurosci 2010, 21, 381-395.
Laverdure-Dupont D, Rainville P, Montplaisir JY, Lavigne GJ. Changes in Rapid Eye Movement Sleep associated with placebo-induced expectations and analgesia. J Neurosci 2009, 29(38), 11745-1152.
Gaput G, Giguère JF, Chauny JM, Denis R, Lavigne GJ. Relationship among subjective sleep complaints headaches, and mood alterations following a mild traumatic brain injury. Sleep Med 2009, 10, 713-716.
Okura K, Lavigne GJ, Huynh N, Manzini C. Filipini D, Montplaisir JY. Comparison of sleep variables between chronic widespread musculoskeletal pain, insomnia, periodic leg movement’s syndrome and control subjects in a clinical sleep medicine practice. Sleep Medicine 2008, 9, 352-361.
Daoust R, Beaulieu P, Manzini C, Chauny JM, Lavigne GJ. Estimation of pain intensity in emergency medicine: a validation study. Pain 2008, 138(3), 565-570.
Pennestri MH, Montplaisir JY, Colombo R, Lavigne GJ, Lanfranchi P. Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology 2007, 68, 1213-1218.
Bélanger L, Vallières A, Ivers H, Moreau V, Lavigne GJ, Morin CM. Meta-analysis of sleep changes in control groups of insomnia treatment trials. J Sleep Med 2007, 16, 77-84.