Research
Obstructive sleep apneas and mild cognitive impairment
Obstructive sleep apnea (OSA) is a major health problem, particularly in the aging population among which OSA is observed in about 20% of individuals. OSA causes sleep disruption and intermittent nocturnal hypoxemia (decrease in the amount of oxygen carried in the blood), which can lead to daytime sleepiness, cognitive deficits, and cerebral dysfunctions. OSA is also recognized as a risk factor for hypertension, cardiovascular and cerebrovascular diseases, and cognitive decline. The main goal of this study is to understand the association between OSA and in older individuals. More specifically, we will study individuals with OSA, individuals with mild cognitive impairment and control subjects in terms of their cognitive functioning (attention, memory, planning capacity) and their brain structures. We will also evaluate the effectiveness of treatment with continuous positive airway pressure (CPAP) to improve sleep apnea and thus improve cognitive functioning. Finally, we will evaluate the predictive value of neuropsychological markers, genetic, electrophysiological and neuroimaging on cognitive health during a three-year follow-up.
Sleep and circadian rhythms after moderate and severe traumatic brain injury
Traumatic brain injury (TBI) is a major public healthcare concern. TBI is the leading cause of mortality in children and young adults in industrial countries. TBI can result in short and long-term cognitive, physical, neurobehavioral and psychological impairments known to interfere with daily living activities and return to work or school. Chronic sleep-wake disturbances, particularly fatigue, hypersomnia, and insomnia, are among the most severe, the most persistent and the most disabling symptoms after TBI. They affect at least 50% of this population and are present across the range of TBI severity. Despite the high prevalence of post-traumatic sleep-wake disturbances and their consequences on quality of life, their emergence and their evolution are still poorly understood. Our research program proposes to objectively measure sleep and circadian rhythms in the acute stage after a TBI, to investigate factors contributing to sleep-wake disturbances and to study the progression of these sleep-wake disturbances over one year.
Publications
Gosselin N, De Beaumont L, Gagnon K, Baril AA, Mongrain V, Blais H, Montplaisir J, Gagnon J-F, Pelleieux S, Poirier J, Carrier J. BDNF Val66Met polymorphism interacts with sleep sonsolidation to predict ability to create new declarative memories. J Neurosci 2016, 36(32), 8390-8398.
Arbour C, Baril AA, Westwick HJ, Potvin MJ, Gilbert D, Giguère JF, Lavigne GJ, Desautels A, Bernard F, Laureys S, Gosselin N. Visual fixation in the ICU: A strong predictor of long-term recovery after moderate-to-severe traumatic brain injuy. Crit Care Med 2016, in press.
Wiseman-Hakes C, Duclos C, Blais H, Dumont M, Bernard F, Desautels A, Menon DK, Gilbert D, Carrier J, Gosselin N. Sleep in the acute phase of severe traumatic brain injury: a snapshot of polysomnography. Neurorehabil Neural Repair 2015, 30(8), 713-21.
Gosselin N, Duclos C. Insomnia following a mild traumatic brain injury: a missing piece to the work disability puzzle? Sleep Med 2016, 20, 155-6.
Baril AA, Gagnon K, Arbour C, Soucy JP, Montplaisir J, Gagnon JF, Gosselin N. Regional cerebral blood flow during wakeful rest in older subjects with mild to severe obstructive sleep apnea. SLEEP 2015, 38(9), 1439-1449.
Arbour C, Khoury S, Lavigne GJ, Gagnon K, Poirier G, Montplaisir JY, Carrier J, Gosselin N. Are NREM sleep characteristics associated to subjective sleep complaints after mild traumatic brain injury? Sleep Med 2015, 16(4), 534-539.
Duclos C, Dumont M, Wiseman-Hakes C, Arbour C, Mongrain V, Gaudreault PO, Khoury S, Lavigne G, Desautels A, Gosselin N. Sleep and wake disturbances following traumatic brain injury. Patho Biol (Paris) 2014, 62(5), 252-261.
Duclos C, Beauregard MP, Bottari C, Ouellet MC, Gosselin N. The impact of poor sleep on cognition and activities of daily living after traumatic brain injury: A review. Aust Occup Ther J 2014, 62(1), 2-12.
Gagnon K, Baril AA, Gagnon JF, Fortin M, Décary A, Lafond C, Desautels A, Montplaisir J, Gosselin N. Cognitive impairment in obstructive sleep apnea. Patho Biol (paris) 2014, 62(5), 233-240.
Duclos C, Dumont M, Blais H, Paquet J, Laflamme E, de Beaumont L, Wiseman-Hakes C, Menon DK, Bernard F, Gosselin N. Rest-activity cycle disturbances in the acute phase of moderate to severe traumatic brain injury. Neurorehabil Neural Repair 2013, 28(5), 472-482.
Gaudreault PO, Gagnon JF, Montplaisir J, Vendette M, Postuma RB, Gagnon K, Gosselin N. Abnormal occipital event-related potentials in Parkinson's disease with concomitant REM sleep behavior disorder. Parkinsonism Relat Disord 2013, 19(2), 212-217.
Sanchez E, El-Khatib H, Arbour C, Bedeti C, Blais H, Marcotte K, Baril AA, Descoteaux M, Gilbert D, Carrier J, Gosselin N. Brain white matter damage and its association with neuronal synchrony during sleep,. Brain (IF : 10), Submitted.
Gagnon K, Baril AA, Montplaisir J, Carrier J, Chami S, Gauthier S, Lafond C, Gagnon JF, Gosselin N. (2018) Detection of mild cognitive impairment in middle-aged and older adults with obstructive sleep apnea, European Respiratory Journal (IF : 12.0), in press. Sep 6. pii: 1801137. doi: 10.1183/13993003.01137-2018.
Baril AA, Carrier J, Lafrenière A, Warby S, Poirier J, Osorio R, Ayas N, Dubé MP, Petit D, Gosselin N. (2018) Biomarkers of dementia in obstructive sleep apnea, Sleep Medecine Reviews (IF : 9.0), in press. 13 Aug, https://doi.org/10.1016/j.smrv.2018.08.001
Baril AA, Gagnon K, Brayet K, Montplaisir J, De Beaumont L, Carrier J, Lafond C, L'Heureux F, Gagnon JF, Gosselin N. (2017) Gray matter hypertrophy and thickening with obstructive sleep apnea in middle-aged and older adults, Am J Respire Crit Care Med 195 (11), 1509-2018.
Duclos C, Dumont M, Arbour C, Paquet J, Blais H, Menon DK, De Beaumont L, Bernard F, Gosselin N. (2017) Parallel recovery of consciousness and sleep in acute traumatic brain injury, Neurology 88(3), 268-275.